Laboratory for Conservation and Utilization of Bio-Resources & Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming 650091, P. R. China
J. Am. Chem. Soc., Article ASAP
DOI: 10.1021/ja3104044
Publication Date (Web): December 4, 2012
Copyright © 2012 American Chemical Society
Macrocyclic PKS-NRPS hybrid metabolites represent a unique family of natural products mainly from bacteria with broad and outstanding biological activities. However, their distribution in fungi has rarely been reported, and little has been reported regarding their nematocidal activity. Here we describe an unprecedented class of PKS-NRPS hybrid metabolites possessing a 13-membered lactam-bearing macrolactone, thermolides A–F (1–6) from a thermophilic fungus Talaromyces thermophilus. We showed that 1 and 2 displayed potent inhibitory activity against three notorious nematodes with LC50 values of 0.5–1 μg/mL, as active as commercial avermectins. This work provided a new class of promising lead compounds for nematocide discovery.
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