Rapid Fabrication of Complex 3D Extracellular Microenvironments by Dynamic Optical Projection Stereolithography

1. A. Ping Zhang^1,2,*, 
2. Xin Qu¹, 
3. Pranav Soman¹, 
4. Kolin C. Hribar¹, 
5. Jin W. Lee¹,
6. Shaochen Chen^1,*, 
7. Sailing He²

Article first published online: 12 JUL 2012

DOI: 10.1002/adma.201202024

The topographic features of the extracelluar matrix (ECM) lay the foundation for cellular behavior. A novel biofabrication method using a digital-mirror device (DMD), called dynamic optical projection stereolithography (DOPsL) is demonstrated. This robust and versatile platform can generate complex biomimetic scaffolds within seconds. Such 3D scaffolds have promising potentials for studying cell interactions with microenvironments in vitro and in viv