† Département de Chimie, Université de Sherbrooke, Sherbrooke, Québec, Canada J1K 2R1
‡ 4D LABS, Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, Canada V5A 1S6
J. Am. Chem. Soc., Article ASAP
DOI: 10.1021/ja308876j
Publication Date (Web): September 26, 2012
Copyright © 2012 American Chemical Society
Using a photosensitive hybrid hydrogel loaded with upconversion nanoparticles (UCNPs), we show that continuous-wave near-infrared (NIR) light (980 nm) can be used to induce the gel–sol transition and release large, inactive biomacromolecules (protein and enzyme) entrapped in the hydrogel into aqueous solution “on demand”, where their bioactivity is recovered. This study is a new demonstration and development in harnessing the unique multiphoton effect of UCNPs for photosensitive materials of biomedical interest.
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