Eggshell-Inspired Biomineralization Generates Vaccines that Do Not Require Refrigeration

1. Guangchuan Wang¹, 
2. Xiaofeng Li², 
3. Lijuan Mo³, 
4. Zhiyong Song¹, 
5. Wei Chen¹, 
6. Yongqiang Deng², 
7. Hui Zhao², 
8. Ede Qin², 
9. Prof. Dr. Chengfeng Qin^2,*, 
10. Prof. Dr. Ruikang Tang^1,*

Article first published online: 24 SEP 2012

DOI: 10.1002/anie.201206154

We’re not gonna bake it: In situ biomineralization creates an egg-like shell on vaccine particles to improve their thermostability. Different from the bare vaccine (squares), the biomineralized vaccine (red circles) can be stored at ambient temperature without refrigeration for up to a week and retain biological activity both in vitro (see graph), as well as in a mouse model.