Sunday, January 13, 2013

Inside Back Cover: Light-Triggered Sequence-Specific Cargo Release from DNA Block Copolymer–Lipid Vesicles

Dr. Alberto Rodríguez-Pulido1, Alina I. Kondrachuk1, Dr. Deepak K. Prusty1, Jia Gao2Prof. Dr. Maria A. Loi2, Prof. Dr. Andreas Herrmann1,*



Sequence-specific cargo release from DNA-encoded lipid vesicles through the stable tagging of a liposome surface with amphiphilic DNA block copolymers (DBCs) is reported by A. Herrmann and co-workers in their Communication on page 1008 ff. Hybridization of anchored DBCs with an oligonucleotide photosensitizer is the key to light-induced singlet oxygen generation close to the lipid membrane, which results in the oxidation of polymer anchors and/or unsaturated phospholipids, leading to release of the vesicle payload.

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