Polymer Pen Lithography (PPL)-Induced Site-Specific Click Chemistry for the Formation of Functional Glycan Arrays

1. Shudan Bian^1,†, 
2. Jiajun He^2,†, 
3. Kevin B. Schesing¹, 
4. Adam B. Braunschweig^1,*

Article first published online: 10 APR 2012

DOI: 10.1002/smll.201102707

Polymer pen lithography (PPL) can be combined with the Cu^I-catalyzed azide–alkyne click reaction to create molecular arrays with control over orientation and sub-1 μm feature sizes over cm² areas. The process has been applied to the deposition of carbohydrates to form functional glycochips.